Dwelling Remedies For Hair Loss
I’d like to start by saying how amazing this webpage is and all of the great data that Ted and all the members provide. A little background; I began Acctuane July of 2010 and bought off it in December of 2011. I took anyplace from 40-eighty mg a day. I saw a lace wig ponytails previous submit on Acctuane and hair loss on this forum and I’ve been following it to a T for the final four months will little success. I am 18 years previous and had the thickest head of hair earlier than Accutane and that i don’t have any household historical past of baldness on either aspect of my household. I’m 100% sure that I am shedding hair as a consequence of Accutane. It is not in the MPB sample, it is generally diffusing all over. I have taken so many supplements in attempt to counteract my hair loss, here are some:
N-acetyl Cysteine (1500mg)
Riboflavin 5- Phosphate (36.5mg)
B Advanced (Activated/co-enzymated 3x daily)
Molybdenum Picolinate (1, 000mg)
Phytisone Adrenal Complicated (3x day by day)
AC Grace Vitamin E (1200 IU)
Glutathione (2x daily)
Thorne Mediclear (2x day by day)
Prescript Assist soil based mostly probiotic (2x each day)
Niacinamide (1, 000 mg)
Manganese Sulfate (400mg)
Fish oil (2x a day)
Vitamin C (5000mg)
Vitamin D (6000 IU)
As you may see, I have experimented with too much of various supplements and it is fairly overwhelming. The hair loss did not start till 2 months after my course was over. I feel like none of these are getting to the supply of my problem which I believe to be cell divison. Accutane is a chemotherapy agent and acts by suppressing cell division and proliferation. I’ve finished copious quantities of analysis during the last eight months and feel like I get so close to the answer.
“Retinoic acid (energetic type of Accutane) induces differentiation and reduces proliferation of stem and progenitor cells. It really works on acne by inducing related occasions in basal sebocytes. These similar actions additionally lead to 13-cis-retinoic’s (Accutane’s) side effects, and these are directed in the direction of proliferating cells within the adult comparable to within the skin, gut and bone. “
“A large ranging effect of retinoic acid is to inhibit proliferation in dividing cells, and this accounts for its frequent consideration as an anti-cancer agent.”
“Deleting telomere elongation capability throughout the physique would also be life-threatening, as a result of it will imply that our regular, proliferating cells (like these in the skin or the lining of the intestine) would all of a sudden have iron limits lace wig ponytails on their skill to reproduce themselves and thus replenish tissue. From the second that we denuded our cells of telomerase, a clock would be ticking. With each division the telomere would shorten by a notch from no matter it had been after we took telomerase out. We could be underneath the specter of a rather horrible demise, as our stem cells went offline one after the other beneath replicative senescence with every failure of a stem cell chargeable for supplying key functions, the tissue would fail to be renewed and would slowly degenerate. “(De Gray, 297)
To sum all of this up, the proof we currently have is that long term remedy with ATRA (all-trans retinoic acid), which is sort of chemically similar to Accutane, causes “telomere shortening, progress arrest, and cell death.”
Accutane induces cell apoptosis. It down-regulates the telomerase enzyme and shortens the telomere size so the cells cannot divide as a lot anymore.
Numerous components have an effect on the quantity and activity of androgen receptors in dermal papilla cells. Retinoic acid (vitamin A derivative), if used for a very long time, might cut back the number of androgen receptors by 30 – 40 %.  Vitamin B6 reduces by 35-40% the extent of protein synthesis observed after androgen receptor activation.  A polypeptide with molecular weight of 60 kDa, analogous to an intracellular calcium-binding protein called calreticulin, prevents binding of the androgen-receptor complicated to DNA and likewise results in the production of calreticulin.
Medication producing hair loss:
Medicine might affect hair follicles in anagen in two methods: by stopping mitosis in matrix cells (anagen effluvium) or by inducing transition of hair follicles from anagen to premature telogen (telogen effluvium). Anagen effluvium ensues a few days or weeks after drug administration,  and telogen effluvium only after two to four months. In each instances hair loss is reversible. Anagen effluvium may be produced by cytotoxic medication (alkylating agents, alkaloids) and telogen by: heparin, vitamin A and its derivatives, interferons, angiotensin changing enzyme blockers, beta-blockers (propranolol, metoprolol), the antiepileptic trimethadione, levodopa, nicotinic acid, salts of gold, lithium, cimetidine, amphetamine, isoniazid and antiinflammatory medication (ibuprofen, acetylsalicylic acid).
I really feel as if there was a means to extend cell division that the hair loss could possibly be reversed. It states within the last paragraph that “in each instances hair loss is reversible”. I hope that this is the case and that I just have telegon effluvium and never permenant alopecia.
Without having a scientific background it is difficult to connect the items and provide you with a solution. Ted- if you possibly can decipher all of this and make some connection between it, it will imply the world to me and plenty of different Accutane sufferers.
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